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The film briefly references Mayanism, the Mesoamerican Long Count calendar, and the 2012 phenomenon in its portrayal of cataclysmic events unfolding in the year 2012.

In 2012, Jackson Curtis (John Cusack) is a writer in Los Angeles who works part time as a limousine driver for Russian billionaire Yuri Karpov. Jackson's ex-wife Kate (Amanda Peet) and their children Noah and Lily live with her new boyfriend, plastic surgeon and amateur pilot Gordon. Jackson takes Noah and Lily on a camping trip to Yellowstone National Park, where they meet Charlie Frost, a radio show host and conspiracy theorist. Charlie supports a theory that suggests the Mayans predicted the world would come to an end in 2012, and claims he has knowledge of the ark project and possesses a map of the arks' location. The family returns home as cracks begin to develop along the San Andreas Fault in California and earthquakes occur in the San Francisco Bay area. Jackson grows suspicious and rents a private plane to rescue his family. He collects his family and Gordon when the Earth's crust displacement begins and they escape Los Angeles as it collapses into the Pacific Ocean.